Deaccelerated Myogenesis and Autophagy in Genetically Induced Pulmonary Emphysema.

ABSTRACT: Patients with chronic obstructive pulmonary disease (COPD)-pulmonary emphysema often develop locomotor muscle dysfunction, which entails reduced muscle mass and force-generation capacity and is associated with worse outcomes, including higher mortality. Myogenesis contributes to adult muscle integrity during injury-repair cycles. Injurious events crucially occur in the skeletal muscles of patients with COPD in the setting of exacerbations and infections, which lead to acute decompensations for limited periods of time, after which patients typically fail to recover the baseline status they had before the acute event. Autophagy, which is dysregulated in muscles from patients with COPD, is a key regulator of muscle stem-satellite- cells activation and myogenesis, yet very little research has

SUBMITTER: Balnis J 

PROVIDER: S-EPMC9163640 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature