Surrogate Endpoints for Late Kidney Transplantation Failure.

ABSTRACT: In kidney transplant recipients, late graft failure is often multifactorial. In addition, primary endpoints in kidney transplantation studies seek to demonstrate the short-term efficacy and safety of clinical interventions. Although such endpoints might demonstrate short-term improvement in specific aspects of graft function or incidence of rejection, such findings do not automatically translate into meaningful long-term graft survival benefits. Combining many factors into a well-validated model is therefore more likely to predict long-term outcome and better reflect the complexity of late graft failure than using single endpoints. If conditional marketing authorization could be considered for therapies that aim to improve long-term outcomes following kidney transplantation, then the surro

SUBMITTER: Naesens M 

PROVIDER: S-EPMC9163814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature