Alloimmune Risk Stratification for Kidney Transplant Rejection.

ABSTRACT: Different types of kidney transplantations are performed worldwide, including biologically diverse donor/recipient combinations, which entail distinct patient/graft outcomes. Thus, proper immunological and non-immunological risk stratification should be considered, especially for patients included in interventional randomized clinical trials. This paper was prepared by a working group within the European Society for Organ Transplantation, which submitted a Broad Scientific Advice request to the European Medicines Agency (EMA) relating to clinical trial endpoints in kidney transplantation. After collaborative interactions, the EMA sent its final response in December 2020, highlighting the following: 1) transplantations performed between human leukocyte antigen (HLA)-identical donors and rec

SUBMITTER: Bestard O 

PROVIDER: S-EPMC9163827 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature