Secondary Nucleation by Interparticle Energies. III. Nucleation Rate Model.

ABSTRACT: A nucleation rate model for describing the kinetics of secondary nucleation caused by interparticle energies (SNIPEs) is derived theoretically, verified numerically, and validated experimentally. The theoretical derivation reveals that the SNIPE mechanism can be viewed as enhanced primary nucleation, i.e., primary nucleation with a lower thermodynamic energy barrier (for nucleation) and a smaller critical nucleus size, both caused by the interparticle interactions and the associated energy between the surface of a seed crystal and a molecular cluster in solution, as shown in part I of this series. In the case of a sufficiently agitated suspension, the model depends on four parameters: two reflecting primary nucleation kinetics and the other two accounting for the intensity and effective sp

SUBMITTER: Ahn B 

PROVIDER: S-EPMC9164201 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature