Expeditive Synthesis of Potent C20-epi-Amino Derivatives of Salinomycin against Cancer Stem-Like Cells.

ABSTRACT: As a continuation of our studies toward the development of small molecules to selectively target cancer stem cells (CSCs), a library of 18 novel derivatives of salinomycin (Sal), a naturally occurring polyether ionophore, was synthesized with a good overall yield using a one-pot Mitsunobu-Staudinger procedure. Compared to the parent structure, the newly synthesized products contained the mono- or disubstituted C20-epi-amine groups. The biological activity of these compounds was evaluated against human mammary mesenchymal HMLER CD24^low/CD44^high cells, a well-established model of breast CSCs, and its isogenic epithelial cell line (HMLER CD24^high/CD44^low) lacking CSC properties. Importantly, the vast majority of Sal derivatives

SUBMITTER: Czerwonka D 

PROVIDER: S-EPMC9164233 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature