Identification of Patients with Preclinical Heart Failure with preserved Ejection Fraction Using the H₂FPEF Score.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) is a common disorder with few effective treatments. There is currently no evidence-based method to identify preclinical HFpEF. The H₂FPEF score is a validated instrument to identify patients with overt HFpEF. Here we show the H₂FPEF score can identify individuals with preclinical HFpEF. Among individuals where heart failure was excluded (n=160), increasing H₂FPEF score was shown to be associated with greater left atrial dilation, left ventricular hypertrophy, and more severe diastolic dysfunction. Patients with increasing H₂FPEF score displayed higher pulmonary artery pressures, higher left heart filling pressures, lower cardiac index, and more severely impaired aerobic capacity during exerci

SUBMITTER: Koepp KE 

PROVIDER: S-EPMC9164289 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature