A pyroptosis-related gene signature predicts prognosis and immune microenvironment in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a highly malignant tumor with a very poor prognosis. Pyroptosis is an inflammatory form of cell death and plays an important role in cancer development. The prognostic value of pyroptosis-related genes (PRGs) in HCC has not been studied extensively.

Methods

Unsupervised consensus clustering analysis was performed to identify two subtypes based on the expression profiles of prognostic PRGs in the The Cancer Genome Atlas (TCGA) database, and the differences between the two subtypes were compared. A prognostic model based on four PRGs was established by further least absolute shrinkage and selection operator (LASSO) Cox regression analysis and multivariate Cox regression analysis.

Results

Two subtypes (clusters 1 and 2) were i

SUBMITTER: Jin Y 

PROVIDER: S-EPMC9164458 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature