Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis.
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ABSTRACT:
SUBMITTER: Xie Y
PROVIDER: S-EPMC9164506 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis.
Xie Yizhao Y Wang Biyun B Zhao Yannan Y Tao Zhonghua Z Wang Ye Y Chen Guangliang G Hu Xichun X
Journal of hematology & oncology 20220603 1
Ferroptosis, a novel non-apoptotic form of cell death, can induce tumor cell death and treatment resistance. Lipid metabolism is closely related to ferroptosis; however, the effect of mammary adipocytes on breast cancer ferroptosis remains to be elucidated. Here, we established the co-culture system of adipocyte-breast cancer cells and revealed the protection of triple-negative breast cancer from ferroptosis by adipocytes. Then, we performed the lipidomics analysis comparing lipid metabolites of ...[more]
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