Sequence Proven Reinfections with SARS-CoV-2 at a Large Academic Center.

ABSTRACT:

Background

Increased reinfection rates with SARS-CoV-2 have recently been reported, with some locations basing reinfection on a second positive PCR test at least 90 days after initial infection.

Methods

We identified cases where patients had two positive tests for SARS-CoV-2 and evaluated which of these had been sequenced as part of our surveillance efforts, and evaluated sequencing and clinical data.

Results

750 patients (920 samples) had a positive test at least 90 days after the initial test. The median time between tests was 377 days, and 724 (79%) of the post 90-day positives were collected after the emergence of the Omicron variant in November 2021. Sequencing was attempted on 231 samples and successful in 127. Successful sequencing spiked during the Omicron sur

SUBMITTER: Morris CP 

PROVIDER: S-EPMC9164520 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature