Impact of a blood-stage vaccine on <i>Plasmodium vivax</i> malaria.

ABSTRACT:

Background

There are no licensed vaccines against Plasmodium vivax , the most common cause of malaria outside of Africa.

Methods

We conducted two Phase I/IIa clinical trials to assess the safety, immunogenicity and efficacy of two vaccines targeting region II of P. vivax Duffy-binding protein (PvDBPII). Recombinant viral vaccines (using ChAd63 and MVA vectors) were administered at 0, 2 months or in a delayed dosing regimen (0, 17, 19 months), whilst a protein/adjuvant formulation (PvDBPII/Matrix-M™) was administered monthly (0, 1, 2 months) or in a delayed dosing regimen (0, 1, 14 months). Delayed regimens were due to trial halts during the COVID-19 pandemic. Volunteers underwent heterologous controlled human malaria infection (CHMI) with blood-stage P. viva

SUBMITTER: Hou MM 

PROVIDER: S-EPMC9164524 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature