Nicotinamide drives T cell activation in the mammary tumor microenvironment.
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ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC9164530 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Nicotinamide drives T cell activation in the mammary tumor microenvironment.
Hu Yang Y Bloy Norma N Elemento Olivier O Buqué Aitziber A
Journal of translational medicine 20220603 1
Nicotinamide (NAM, a variant of vitamin B<sub>3</sub>) has recently been shown to accelerate the activation of human CD4<sup>+</sup> and CD8<sup>+</sup> T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells infiltrating mouse mammary carcinomas that are therapeutically controlled by NAM also express multiple markers of late-stage activation. Taken together, these findings lend additional support to the notion that the antineoplastic effects of NAM involve at le ...[more]
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