Molecular imaging phenotyping for selecting and monitoring radioligand therapy of neuroendocrine neoplasms.

ABSTRACT: Neuroendocrine neoplasia (NEN) is an umbrella term that includes a widely heterogeneous disease group including well-differentiated neuroendocrine tumours (NETs), and aggressive neuroendocrine carcinomas (NECs). The site of origin of the NENs is linked to the intrinsic tumour biology and is predictive of the disease course. It is understood that NENs demonstrate significant biologic heterogeneity which ultimately translates to widely varying clinical presentations, disease course and prognosis. Thus, significant emphasis is laid on the pre-therapy evaluation of markers that can help predict tumour behavior and dynamically monitors the response during and after treatment. Most well-differentiated NENs express somatostatin receptors (SSTRs) which make them appropriate for peptide receptor ra

SUBMITTER: Iravani A 

PROVIDER: S-EPMC9164531 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature