C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study.

ABSTRACT:

Background

Systemic inflammation has been linked to diseases and frailty. However, little is known about the effect of systemic inflammation on frailty progression with a longitudinal study design.

Objectives

This study aimed to investigate the associations of two inflammation indicators, C-reactive protein (CRP) and white blood cell (WBC), with frailty progression.

Methods

This study utilized data from the China Health and Retirement Longitudinal Study 2011-2018 (wave 1-wave 4). Frailty index (FI) was calculated using 40 items from wave 1 to wave 4 (range: 0 to 1). Two systemic inflammation biomarkers, CRP and WBC, were measured at baseline (wave 1) and logs transformed as continuous variables or grouped using quartiles. Linear mixed-effect models were used to analyz

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC9164533 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature