Flow cytometry optimizing the diagnostic approach in inborn errors of immunity: experience from Egypt.

ABSTRACT:

Background

Human inborn errors of immunity (IEI) are a group of inherited genetic disorders of the immune system. IEI Patients suffer from severe repeated infections, autoimmunity, lymphadenopathy and/or increased susceptibility to malignancies. IEI are due to absence, disproportion, or loss of function of immune cells; mostly inherited in autosomal recessive manner, hence are more common in countries with high rate of consanguinity. Definite diagnosis of IEI is achieved by genetic analysis, however it is not always available.

Aim

to report on different IEI categories and impact of expanding the use of flow cytometry (FCM) in diagnosis, categorization and follow up of IEI patients in a highly consanguineous population.

Methods

Retrospective chart review on different I

SUBMITTER: Meshaal S 

PROVIDER: S-EPMC9164555 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature