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Clinical impact of glycans in platelet and megakaryocyte biology.

ABSTRACT: Humans produce and remove 1011 platelets daily to maintain a steady-state platelet count. The tight regulation of platelet production and removal from the blood circulation prevents anomalies in both processes from resulting in reduced or increased platelet count, often associated with the risk of bleeding or overt thrombus formation, respectively. This review focuses on the role of glycans, also known as carbohydrates or oligosaccharides, including N- and O-glycans, proteoglycans, and glycosaminoglycans, in human and mouse platelet and megakaryocyte physiology. Based on recent clinical observations and mouse models, we focused on the pathologic aspects of glycan biosynthesis and degradation and their effects on platelet numbers and megakaryocyte function.

SUBMITTER: Falet H

PROVIDER: S-EPMC9164739 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Clinical impact of glycans in platelet and megakaryocyte biology.

Falet Hervé H Rivadeneyra Leonardo L Hoffmeister Karin M KM

Blood 20220601 22

Humans produce and remove 1011 platelets daily to maintain a steady-state platelet count. The tight regulation of platelet production and removal from the blood circulation prevents anomalies in both processes from resulting in reduced or increased platelet count, often associated with the risk of bleeding or overt thrombus formation, respectively. This review focuses on the role of glycans, also known as carbohydrates or oligosaccharides, including N- and O-glycans, proteoglycans, and glycosami ...[more]

PMID: 35015813

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