Early diagnosis of anastomotic leakage after colorectal cancer surgery using an inflammatory factors-based score system.

ABSTRACT:

Background

Anastomotic leakage (AL) is a severe complication after colorectal surgery. This study aimed to investigate a method for the early diagnosis of AL after surgical resection by analysing inflammatory factors (IFs) in peritoneal drainage fluid.

Methods

Abdominal drainage fluid of patients with colorectal cancer who underwent resection between April 2017 and April 2018, were prospectively collected in the postoperative interval. Six IFs, including interleukin (IL)-1β, IL-6, IL-10, tumour necrosis factor (TNF)-α, matrix metalloproteinase (MMP)2, and MMP9, in drainage were determined by multiplex immunoassay to investigate AL (in patients undergoing resection and anastomosis) and pelvic collection (in patients undergoing abdominoperineal resection). Sparreboom and colle

SUBMITTER: Shi J 

PROVIDER: S-EPMC9165091 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature