A consensus view of the proteome of the last universal common ancestor.

ABSTRACT: The availability of genomic and proteomic data from across the tree of life has made it possible to infer features of the genome and proteome of the last universal common ancestor (LUCA). A number of studies have done so, all using a unique set of methods and bioinformatics databases. Here, we compare predictions across eight such studies and measure both their agreement with one another and with the consensus predictions among them. We find that some LUCA genome studies show a strong agreement with the consensus predictions of the others, but that no individual study shares a high or even moderate degree of similarity with any other individual study. From these observations, we conclude that the consensus among studies provides a more accurate depiction of the core proteome of the LUCA an

SUBMITTER: Crapitto AJ 

PROVIDER: S-EPMC9165204 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature