Role of sex hormones in modulating myocardial perfusion and coronary flow reserve.

ABSTRACT:

Background

A growing body of evidence highlights sex differences in the diagnostic accuracy of cardiovascular imaging modalities. Nonetheless, the role of sex hormones in modulating myocardial perfusion and coronary flow reserve (CFR) is currently unclear. The aim of our study was to assess the impact of female and male sex hormones on myocardial perfusion and CFR.

Methods

Rest and stress myocardial perfusion imaging (MPI) was conducted by small animal positron emission tomography (PET) with [¹⁸F]flurpiridaz in a total of 56 mice (7-8 months old) including gonadectomized (Gx) and sham-operated males and females, respectively. Myocardial [¹⁸F]flurpiridaz uptake (% injected dose per mL, % ID/mL) was used as a surrogate for myocardial perfusion at rest and

SUBMITTER: Haider A 

PROVIDER: S-EPMC9165260 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature