Sequence Analysis and Comparison of TCTP Proteins from Human Protozoan Parasites.

ABSTRACT:

Purpose

Translational controlled tumor protein (TCTP) is a functionally important protein in most eukaryotes because it participates in a wide variety of processes, the most representative being proliferation, differentiation, histamine release, cell death, protein synthesis and response to stress conditions. In the present work, we analyze the sequence, structure and phylogeny of TCTP orthologs in a group of human parasitic protozoan species.

Methods

The complete sequences of TCTP orthologs in protozoan parasites were identified with the NCBI BLAST tool in the database of the EuPathDB Bioinformatics Resource Center. The sequences were aligned and important regions of the protein were identified, and later phylogenetic trees and 3D models were built with different bioinforma

SUBMITTER: Lagunas-Rangel FA 

PROVIDER: S-EPMC9165267 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature