Impaired coronary flow reserve in patients with supra-normal left ventricular ejection fraction at rest.

ABSTRACT:

Purpose

Recently, a "U" hazard ratio curve between resting left ventricular ejection fraction (LVEF) and prognosis has been observed in patients referred for routine clinical echocardiograms. The present study sought to explore whether a similar "U" curve existed between resting LVEF and coronary flow reserve (CFR) in patients without severe cardiovascular disease (CVD) and whether impaired CFR played a role in the adverse outcome of patients with supra-normal LVEF (snLVEF, LVEF ≥ 65%).

Methods

Two hundred ten consecutive patients (mean age 52.3 ± 9.3 years, 104 women) without severe CVD underwent clinically indicated rest/dipyridamole stress electrocardiography (ECG)-gated ¹³ N-ammonia positron emission tomography/computed tomography (PET/CT). Major adverse cardi

SUBMITTER: Wu P 

PROVIDER: S-EPMC9165269 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature