Twenty years of experience of a tertiary cancer center in total body irradiation with focus on oncological outcome and secondary malignancies.

ABSTRACT:

Purpose

Total body irradiation (TBI) is a common part of the myelo- and immuno-ablative conditioning regimen prior to an allogeneic hematopoietic stem cell transplantation (allo-HSCT). Due to concerns regarding acute and long-term complications, there is currently a decline in otherwise successfully established TBI-based conditioning regimens. Here we present an analysis of patient and treatment data with focus on survival and long-term toxicity.

Methods

Patients with hematologic diseases who received TBI as part of their conditioning regimen prior to allo-HSCT at Frankfurt University Hospital between 1997 and 2015 were identified and retrospectively analyzed.

Results

In all, 285 patients with a median age of 45 years were identified. Median radiotherapy dose applied

SUBMITTER: Sieker K 

PROVIDER: S-EPMC9165288 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature