The "mitochondrial stress responses": the "Dr. Jekyll and Mr. Hyde" of neuronal disorders.

ABSTRACT: Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions, such as oxidative and metabolic stress, protein folding or import defects, and mitochondrial DNA alteration. Cells engage in different coordinated responses to safeguard mitochondrial homeostasis. In this review, we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions, keep them under control and rescue the physiological condition of nervous cells. In the sections to come, particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion, mitophagy, mitochondrial unfolding protein response, and apoptosis impact human neuronal diseases. Finally, we will discuss

SUBMITTER: Patergnani S 

PROVIDER: S-EPMC9165365 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature