Proteomic-based evidence for adult neurogenesis in birds and mammals as indicated from cerebrospinal fluid.

ABSTRACT: Adult neurogenesis is the life-long process of neural stem cell proliferation, differentiation into neurons, migration, and incorporation into the existing neuronal circuits. After decades of research, it is now widely accepted that mammals and birds retain the capacity to regenerate neurons even after their subadult ontogeny. Cerebrospinal fluid participates in the regulation of the neurogenic niches of the vertebrate brain through signaling pathways not fully elucidated. Proteomic studies of cerebrospinal fluid have the potential to allow the in-depth characterization of its molecular composition. Comparative studies help to delineate those pathways that are universally critical for the regulation of neurogenesis in adulthood. In this review, we performed literature-based data mining in

SUBMITTER: Voukali E 

PROVIDER: S-EPMC9165395 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature