Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC9165477 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Chen Haiyan H Zhou Mengyuan M Zeng Yuteng Y Miao Tongtong T Luo Haoyuan H Tong Yang Y Zhao Mei M Mu Rui R Gu Jiang J Yang Shudi S Han Liang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20220331 16
The blood-brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC-K1) binding to and invasion of BBB endothelial cells in bacterial meningitis, utilization of the BBB invasion ability of the EC-K1 outer membrane for brain-targeted drug delivery and construction of a biomimetic self-assembled nanoparticle with a surface featuring a lipopolysaccharide-free EC-K1 outer membrane ...[more]