Composition and Stability of the Vaginal Microbiota of Pregnant Women With Inflammatory Bowel Disease.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is common in women of childbearing years, and active IBD during pregnancy is associated with increased rates of preterm delivery and low-birth-weight newborns. Changes in the vaginal microbiome have been associated with preterm delivery. We aimed to determine the taxonomic composition of the vaginal microbiota at 3 time points during pregnancy in a population of women with IBD.

Methods

Participants were recruited from the patient registry of the Preconception and Pregnancy IBD Clinic at Royal University Hospital in Saskatoon, Canada. Self-collected vaginal swabs were obtained from patients at each trimester. Microbiota profiles were created by cpn60 amplicon sequencing.

Results

We characterized the vaginal microbiota of 32 p

SUBMITTER: Hill JE 

PROVIDER: S-EPMC9165555 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature