The Cystine/Glutamate Antiporter, System x_c ^-, Contributes to Cortical Infarction After Moderate but Not Severe Focal Cerebral Ischemia in Mice.

ABSTRACT: Understanding the mechanisms underlying ischemic brain injury is of importance to the goal of devising novel therapeutics for protection and/or recovery. Previous work in our laboratory and in others has shown that activation of cystine/glutamate antiporter, system x_c ^- (Sx_c ^-), facilitates neuronal injury in several in vitro models of energy deprivation. However, studies on the contribution of this antiporter to ischemic brain damage in vivo are more limited. Since embolic or thrombotic transient or permanent occlusion of a cerebral blood vessel eventually leads to brain infarction in most stroke cases, we evaluated the contribution of Sx_c ^- to cerebral ischemic damage by comparing brain infarction between mic

SUBMITTER: He Y 

PROVIDER: S-EPMC9165760 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature