The safety of co-administration of Bacille Calmette-Guerin (BCG) and influenza vaccines.

ABSTRACT:

Background

With the emergence of novel vaccines and new applications for older vaccines, co-administration is increasingly likely. The immunomodulatory effects of BCG could theoretically alter the reactogenicity of co-administered vaccines. Using active surveillance in a randomised controlled trial, we aimed to determine whether co-administration of BCG vaccination changes the safety profile of influenza vaccination.

Methods

Participants who received influenza vaccine alone (Influenza group) were compared with those who also received BCG-Denmark vaccine in the contralateral arm (Influenza+BCG group). Data on the influenza vaccination site were collected using serial questionnaires and active follow-up for 3 months post vaccination.

Results

Of 1351 participants in the

SUBMITTER: Villanueva P 

PROVIDER: S-EPMC9165819 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature