Identification and validation of a prognostic signature related to hypoxic tumor microenvironment in cervical cancer.

ABSTRACT:

Background

Hypoxia is a common microenvironment condition in most malignant tumors and has been shown to be associated with adverse outcomes of cervical cancer patients. In this study, we investigated the effects of hypoxia-related genes on tumor progress to characterize the tumor hypoxic microenvironment.

Methods

We retrieved a set of hypoxia-related genes from the Molecular Signatures Database and evaluated their prognostic value for cervical cancer. A hypoxia-based prognostic signature for cervical cancer was then developed and validated using tumor samples from two independent cohorts (TCGA-CESC and CGCI-HTMCP-CC cohorts). Finally, we validated the hypoxia prediction of ccHPS score in eight human cervical cancer cell lines treated with the hypoxic and normoxic conditions

SUBMITTER: Nie C 

PROVIDER: S-EPMC9165826 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature