Combining Serial and Parallel Functionality in Functional Lung Avoidance Radiation Therapy.

ABSTRACT:

Purpose

Functional lung avoidance (FLA) radiation therapy (RT) aims to minimize post-RT pulmonary toxicity by preferentially avoiding dose to high-functioning lung (HFL) regions. A common limitation is that FLA approaches do not consider the conducting architecture for gas exchange. We previously proposed the functionally weighted airway sparing (FWAS) method to spare airways connected to HFL regions, showing that it is possible to substantially reduce risk of radiation-induced airway injury. Here, we compare the performance of FLA and FWAS and propose a novel method combining both approaches.

Methods

We used breath-hold computed tomography (BHCT) and simulation 4-dimensional computed tomography (4DCT) from 12 lung stereotactic ablative radiation therapy patients. Four plann

SUBMITTER: Vicente EM 

PROVIDER: S-EPMC9165847 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature