Correlation between genetic and environmental risk factors for age-related macular degeneration in Brazilian patients.

ABSTRACT:

Purpose

To analyze the correlations between age-related macular degeneration (AMD) and genetic and environmental risk factors for in a Brazilian population.

Design

Cross-sectional study with a control group.

Methods

We collected data on 236 participants 50 years of age or older (141 with AMD and 95 controls without the disease). Data was obtained using a questionnaire and included information on demographics, ocular and medical history, family history of AMD, lifestyle, and smoking and drinking habits. Genetic evaluations included direct sequencing for the LOC387715 (rs10490924) variant, as well as PCR and enzymatic digestion for the CFH Y402H (rs1061170) and HTRA1 (rs11200638) variants. We performed a risk assessment of environmental risk factors and genetic variants

SUBMITTER: Rim PHH 

PROVIDER: S-EPMC9165864 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature