Ibuprofen molecular aggregation by direct back-face transmission steady-state fluorescence.

ABSTRACT: Direct back-face transmission steady-state fluorescence was successfully applied to the study of aggregation of ibuprofen and ibuprofenate anion in solution taking advantage of its own fluorescence. The analysis of the experimental data involves the use of the differential reabsorption model to account for re-absorption phenomenon and the closed association model to describe aggregation. The fluorescence quantum yield of ibuprofenate increases when it aggregates in the presence of sodium, but it markedly decreases when 1-butyl-3-methylimidazolium is used as counterion. The proposed methodology allows the accurate determination of the critical aggregation concentrations and the mean aggregation numbers. Results were supported by complementary techniques such as time-resolved fluorescence, <

SUBMITTER: Steinberg PY 

PROVIDER: S-EPMC9166242 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature