Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.

ABSTRACT:

Background

Forced expiratory volume in 1 second (FEV₁) is central to the diagnosis of chronic obstructive pulmonary disease (COPD) but is imprecise in classifying disease burden. We examined the potential of the maximal mid-expiratory flow rate (forced expiratory flow rate between 25% and 75% [FEF_25%-75%]) as an additional tool for characterizing pathophysiology in COPD.

Objective

To determine whether FEF_25%-75% helps predict clinical and radiographic abnormalities in COPD.

Study design and methods

The SubPopulations and InteRediate Outcome Measures In COPD Study (SPIROMICS) enrolled a prospective cohort of 2978 nonsmokers and ever-smokers, with and without COPD, to identify phenotypes and intermediate markers of disease progression. W

SUBMITTER: Ronish BE 

PROVIDER: S-EPMC9166328 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature