Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus.

ABSTRACT:

Background

Dysregulation of brain fluid homeostasis associates with brain pathologies in which fluid accumulation leads to elevated intracranial pressure. Surgical intervention remains standard care, since specific and efficient pharmacological treatment options are limited for pathologies with disturbed brain fluid homeostasis. Such lack of therapeutic targets originates, in part, from the incomplete map of the molecular mechanisms underlying cerebrospinal fluid (CSF) secretion by the choroid plexus.

Methods

The transcriptomic profile of rat choroid plexus was generated by RNA Sequencing (RNAseq) of whole tissue and epithelial cells captured by fluorescence-activated cell sorting (FACS), and compared to proximal tubules. The bioinformatic analysis comprised mapping to refer

SUBMITTER: Andreassen SN 

PROVIDER: S-EPMC9166438 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature