Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium.

ABSTRACT:

Objectives

Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown. The aim of the present study was to identify novel therapeutic target molecules, the expression patterns of which are affected by MTX in patients with RA.

Methods

CD4⁺ T cells from 28 treatment-naïve patients with RA before and 3 months after the initiation of MTX treatment were subjected to DNA microarray analyses. The expression levels of semaphorin 3G, a differentially expressed gene, and its receptor, neuropilin-2, were evaluated in the RA synovium and collagen-induced arthritis synovium. Collagen-induced arthritis and collagen antibody-induc

SUBMITTER: Shoda J 

PROVIDER: S-EPMC9166515 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature