Applicability of polygenic risk scores in endometriosis clinical presentation.

ABSTRACT:

Background

Risk prediction is an essential part of preventative medicine and in recent years genomic information has become an interesting factor in risk models. Polygenic risk scores (PRS) combine the effect of many genetic variations into a single score which has been shown to have predictive value for many diseases. This study aimed to investigate the association between PRS for endometriosis and the clinical presentation of the disease.

Methods

Women with endometriosis (N = 172) were identified at the Department of Gynecology. All participants answered questionnaires regarding sociodemographic factors, lifestyle habits and medical history, registered bowel symptoms on the Visual Analog Scale for Irritable Bowel Syndrome and passed blood samples. DNA was extracted and sam

SUBMITTER: Svensson A 

PROVIDER: S-EPMC9166598 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature