Role of p38 MAP kinase in cancer stem cells and metastasis.
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ABSTRACT:
SUBMITTER: Kudaravalli S
PROVIDER: S-EPMC9166676 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Role of p38 MAP kinase in cancer stem cells and metastasis.
Kudaravalli Sriya S den Hollander Petra P Mani Sendurai A SA
Oncogene 20220430 23
Therapeutic resistance and metastatic progression are responsible for the majority of cancer mortalities. In particular, the development of resistance is a significant barrier to the efficacy of cancer treatments such as chemotherapy, radiotherapy, targeted therapies, and immunotherapies. Cancer stem cells (CSCs) underlie treatment resistance and metastasis. p38 mitogen-activated protein kinase (p38 MAPK) is downstream of several CSC-specific signaling pathways, and it plays an important role in ...[more]
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