Testing 3D printed biological platform for advancing simulated microgravity and space mechanobiology research.

ABSTRACT: The advancement of microgravity simulators is helping many researchers better understanding the impact of the mechanically unloaded space environment on cellular function and disfunction. However, performing microgravity experiments on Earth, using simulators such as the Random Positioning Machine, introduces some unique practical challenges, including air bubble formation and leakage of growth medium from tissue culture flask and plates, all of which limit research progress. Here, we developed an easy-to-use hybrid biological platform designed with the precision of 3D printing technologies combined with PDMS microfluidic fabrication processes to facilitate reliable and reproducible microgravity cellular experiments. The system has been characterized for applications in the contest of brai

SUBMITTER: Silvani G 

PROVIDER: S-EPMC9166742 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature