Evaluating diagnostic accuracy and determining optimal diagnostic thresholds of different approaches to [⁶⁸Ga]-DOTATATE PET/MRI analysis in patients with meningioma.

ABSTRACT: Multiple approaches with [⁶⁸Ga]-DOTATATE, a somatostatin analog PET radiotracer, have demonstrated clinical utility in evaluation of meningioma but have not been compared directly. Our purpose was to compare diagnostic performance of different approaches to quantitative brain [⁶⁸Ga]-DOTATATE PET/MRI analysis in patients with suspected meningioma recurrence and to establish the optimal diagnostic threshold for each method. Patients with suspected meningioma were imaged prospectively with [⁶⁸Ga]-DOTATATE brain PET/MRI. Lesions were classified as meningiomas and post-treatment change (PTC), using follow-up pathology and MRI as reference standard. Lesions were reclassified using the following methods: absolute maximum SUV threshold (SUV), SUV ratio (SUVR) to su

SUBMITTER: Kim SH 

PROVIDER: S-EPMC9166786 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature