Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy.

ABSTRACT:

Background

Extracorporeal shock wave lithotripsy (ESWL) is considered one of the best choices for the treatment of various kinds of urinary tract calculi, although it might cause acute kidney injury.

Objective

To measure the urinary long non-coding RNA-messenger RNA (LncRNA-mRNA) panel before and after ESWL to evaluate post-ESWL renal injury in a reliable and non-invasive method.

Patients and methods

The study included 60 patients with renal stones treated with ESWL and 30 healthy volunteers. Voided urine samples were obtained before, 2 h, and 1 day after ESWL. We measured the urinary level of LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) by real-time qPCR and compared the results with serum creatinine and eGFR.

Results

LncRNA (SBF2-AS1, FENDRR-19) and mR

SUBMITTER: Tawfick A 

PROVIDER: S-EPMC9166822 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature