Safety pharmacology of acute LSD administration in healthy subjects.

ABSTRACT:

Rationale

Lysergic acid diethylamide (LSD) is used in psychiatric and psychological research and investigated as a potential treatment for medical and psychiatric disorders, including depression, anxiety, and cluster headache.

Objectives

Safety data on clinical safety are available from small studies but not from larger samples. We report safety pharmacology data from a large pooled study sample on acute effects of LSD in healthy subjects.

Methods

We conducted a pooled analysis of four double-blind, randomized, placebo-controlled, crossover studies that included a total of 83 healthy subjects and 131 single-dose administrations of LSD. LSD administrations were matched to dose groups according to measured LSD peak plasma concentrations to adjust for uncertainties in th

SUBMITTER: Holze F 

PROVIDER: S-EPMC9166834 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature