Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants.

ABSTRACT:

Background

LSD and psilocybin are increasingly used in phase I trials and evaluated as therapeutic agents for mental disorders. The phenomenon of reoccurring drug-like experiences after the acute substance effects have worn off was described for both substances and especially attributed to LSD. According to the DSM-V, the persisting and distressing manifestation of these experiences is called hallucinogen-persisting perception disorder (HPPD). Data on both conditions is very limited.

Objective

This study aims to provide descriptive data on reoccurring drug-like experiences after the administration of LSD and psilocybin in controlled studies with healthy participants.

Methods and materials

Data from 142 healthy subjects enrolled in six double-blinded, placebo-controlle

SUBMITTER: Muller F 

PROVIDER: S-EPMC9166883 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature