Identification of Biomarkers of Autophagy-Related Genes Between Early and Advanced Carotid Atherosclerosis.

ABSTRACT:

Background

Accumulating evidence demonstrates that autophagy is important in inhibiting inflammation and cholesterol efflux. It suggested the autophagy may be a treatment of atherosclerosis. Thus, we screened autophagy-related mRNA to explore their mechanism of scientific basis for early diagnosis and therapy of atherosclerosis.

Methods

The GSE28829 datasets were assessed to analyze differentially expressed genes by GEO2R. And autophagy-related hub genes were identified by HADb. The biological function of autophagy-related DEmRNAs was examined by Metascape. The construction of a protein-protein network was explored by String. Cytohubba was utilized to screen hub genes. Analysis of DEmiRNA-mRNA pairs was executed by DIANA microT-CDS database. Finally, correlation analysis was

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9166959 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature