N6-Methyladenosine-Related lncRNAs Are Anticipated Biomarkers for Sarcoma Patients.

ABSTRACT:

Background

Soft tissue sarcomas (STSs) are rare tumors and occur at any site in the body. Our goal was to identify a putative molecular mechanism for N6-methyladenosine (m6A) lncRNA alteration and to develop predictive biomarkers for sarcoma.

Methods

The lncRNA levels were obtained from TCGA datasets. Pearson correlation analysis was used to select all the lncRNAs that are connected to m6A. An m6A-related lncRNA model was built using LASSO Cox regression. To assess the prognostic efficiency of the model and potential lncRNAs, we performed univariate survival analysis and receiver operating characteristic (ROC) analysis. We also performed enrichment analysis to evaluate the roles of the potential genes. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) was u

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9166981 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature