The Influence of Heavy Metals on Gastric Tumorigenesis.

ABSTRACT:

Objectives

This study aimed to observe the relationship among heavy metals concentration, microsatellite instability (MSI), and human epidermal growth factor receptor type 2 (HER2) gene amplification in gastric cancer (GC) patients.

Methods

The concentrations of 18 heavy metals in the plasma of GC patients and healthy controls were measured by inductive coupled plasma emission spectrometry (ICP-MS). MSI detection was conducted by detecting 5 microsatellite repeat markers by PCR analysis. HER2 gene amplification was detected by fluorescence in situ hybridization (FISH). The relationship among heavy metal elements, tumor biomarkers, HER2 amplification, and MSI status was analyzed by Pearson correlation analysis.

Results

A total of 105 GC patients and 62 healthy controls

SUBMITTER: Wang L 

PROVIDER: S-EPMC9167133 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature