Neurophysiological Deficits During Reappraisal of Negative Emotional Stimuli in Opioid Misuse.

ABSTRACT:

Background

Opioid misuse is hypothesized to compromise the ability to regulate negative emotions, as manifested through visceral and peripheral physiological signals. However, neurophysiological impairment of top-down cognitive emotion regulation in opioid misuse has not previously been shown.

Methods

Patients with chronic pain who had been taking opioids for 90 days or longer (N = 149; female, n = 98) underwent a negative emotion regulation task with electroencephalography. Participants were instructed to view or reappraise negative images presented for 3 seconds. Using a validated cutoff score on the Current Opioid Misuse Measure, participants were classified as exhibiting aberrant drug-related behavior consistent with opioid misuse (MISUSE+) or as being low risk for opioi

SUBMITTER: Hudak J 

PROVIDER: S-EPMC9167218 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature