GLUT-2 mediated glucose uptake analysis of Duranta repens: In-silico and In-vitro approach.

ABSTRACT:

Background

Type-2 diabetes mellitus is a common metabolic disorder characterized by insulin resistance, a relative impairment in insulin secretion, and a certain degree of genetic predisposition. The rapid rise in the prevalence of diabetes mellitus around the world has assisted in the development of new pharmacologically active compounds. The current study was aimed to investigate and validate the anti-diabetic activity of wild-grown plant Duranta repens L.

Material and methods

In-silico molecular docking via AutoDock tools 4.2 and in-vitro glucose uptake assay using yeast cells was performed to investigate the anti-diabetic property of plant Duranta repens. Further, mRNA-based gene ontology enrichment analysis was performed to predict the

SUBMITTER: Patil A 

PROVIDER: S-EPMC9167272 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature