Lack of association between CYP27B1 gene polymorphism and type 2 diabetes mellitus in Iranian patients.

ABSTRACT:

Purpose

Type 2 diabetes mellitus (T2DM) is a global health problem with multiple etiological factors. Previous studies indicated that 1- alpha, 25-dihydroxyvitamin D3, a molecule that is produced by CYP27B1, could protect insulin-secreted cells from destruction by immune cells. The aim of the study was to investigate the CYP27B1 promoter gene polymorphism in T2DM.

Methods

Two hundred subjects including 100 T2DM and 100 healthy individuals were recruited in the study. ARMS-PCR technique was used to identify rs10877012 genotypes in the 5' region of CYP27B1.

Results

The frequency of CC, CA, and AA genotype was 61/50, 31/39, and 8/11, respectively in T2DM patients compared to healthy subjects. There was no significant difference between both groups in regarding to genotyp

SUBMITTER: Erfanian S 

PROVIDER: S-EPMC9167340 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature