Meta-analysis of HNF1A-MODY3 variants among human population.

ABSTRACT:

Background

Previously, numerous case-control studies have highlighted variants responsible for Maturity onset diabetes of young (MODY). However, these studies have been conducted among diverse populations and hence yielded contradictory results. We, therefore, performed a meta-analysis to precisely find the association of SNPs with the disease for the HNF1A gene.

Objective

Meta-analysis of clinically defined studies deciphering mutations in the HNF1A gene responsible for the development of MODY3 was conducted among various populations to determine associations using statistical approaches.

Methods

The curation of 505 research articles published between the years 2000-2021 was carried out. Visualization of data-related protocols and statistical-analysis were conducted,

SUBMITTER: Behl R 

PROVIDER: S-EPMC9167412 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature