Synthetic condensate size correlates with yeast replicative cell age.
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ABSTRACT:
SUBMITTER: Heidenreich M
PROVIDER: S-EPMC9167435 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Synthetic condensate size correlates with yeast replicative cell age.
Heidenreich Meta M Georgeson Joseph M JM Nadav Yotam Y Levy Emmanuel D ED
microPublication biology 20220603
Yeast divides asymmetrically, with an aging mother cell and a 'rejuvenated' daughter cell, and serves as a model organism for studying aging. At the same time, determining the age of yeast cells is technically challenging, requiring complex experimental setups or genetic strategies. We developed a synthetic system composed of two interacting oligomers, which forms condensates in living yeast cells. Here, we report that these synthetic condensates' size correlates with yeast replicative age, maki ...[more]
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