Exosome-Derived miRNAs as Potential Biomarkers for Prostate Bone Metastasis.

ABSTRACT:

Purpose

The purpose of this study was to identify the potential exosome-derived microRNAs (miRNAs) related to prostate cancer (Pca) bone metastasis.

Methods

Two datasets were collected. One dataset was from the authors' institute, for which two groups of 10 patients each were designed: in the first one, the patients had early-stage localised Pca without bone metastasis, and in the other, the patients presented with Pca with bone metastasis. Then, the miRNA expression profiles of the blood exosomes were obtained and analysed. The other dataset was a public dataset of the miRNA expression transcriptome (GSE26964), which was downloaded from Gene Expression Omnibus (GEO). The results of both datasets were jointly analysed and the most bone-metastatic-related differentially expre

SUBMITTER: Lu Z 

PROVIDER: S-EPMC9167626 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature